Description
Provides insight into the involvement of free radicals in the pathogenesis of chemical-induced toxic tissue injury. The text addresses the fundamentals of free radical chemistry and the theoretical basis for electron transfer reaction leading to free radical generation. It describes the various subcellular sources of free radicals, the biological reactivity with lipid, protein and nucleic acids, and the physiochemical determinants of free radical-induced cell injury and the various antioxidant defence systems. The book focuses on target organ toxicity, and the concluding section offers an overview of the evidence implicating free radicals in the aetiology of various chemical toxicities, challenging the possibility of misguided use of biomarkers for oxidative damage.
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Describes the involvement of free radicals in the pathogenesis of chemical-induced toxic tissue injury. Part I explains free radical chemistry and progress through descriptions of biological sources and molecular targets of free radicals in cell systems. Part II discusses target organ selective toxicities, and Part III gives examples of specific chemicals causing injury to each tissue. The molecular and biochemical mechanisms responsible for toxicity are emphasized. Part IV addresses the molecular biology of free-radical mediated alterations in gene expression, signal transduction, and carcinogenesis, and provides an overview of evidence implicating free radicals in the etiology of various chemical toxicities. For researchers in areas such as toxicology, xenobiotics, pharmacology, and environmental health. Annotation c. by Book News, Inc., Portland, Or.
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