Description
High throughput screening (HTS) is a tool in the discovery of pharmaceutical, chemical, and agricultural compounds. This work describes technologies and techniques used in HTS and demonstrates how they can be applied generically. It details biological techniques involved, discusses the management of compound libraries, and explains the automation and engineering approaches needed. Specific topics discussed include purchasing and installing robotic systems, configuring radioligand receptor binding assays for HTS using scintillation proximity assay technology, and cellular assays in HTS. The book can be used as a training tool and as a resource for practitioners. Janzen is a researcher in the private sector. Annotation c. Book News, Inc., Portland, OR (booknews.com)
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In High Throughput Screening, leading scientists and researchers expert in molecular discovery explain the diverse technologies and key techniques used in HTS and demonstrate how they can be applied generically. Writing to create precisely the introductory guidebook they wish had been available when they started in HTS, these expert seasoned authors illuminate the HTS process with richly detailed tutorials on the biological techniques involved, the management of compound libraries, and the automation and engineering approaches needed. Extensive discussions provide readers with all those key elements of pharmacology, molecular biology, enzymology, and biochemistry that will ensure the identification of suitable targets and screens, and detail the technology necessary to mine millions of data points for meaningful knowledge.
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