Description
Examines when and why the antibody isotype responsible for allergic reactions is produced, as a step toward developing appropriate treatment for the 20% of the general population who suffer from allergic disorders. Discusses how T cells direct IgE switching, its regulation in tissues, cytokine signal transduction and its role in isotype class switching, antibody recognition of recombinant allergens and allergen-fragments, isoforms of IgE, and other topics. Of interest both to basic scientists and to clinicians in immunology, molecular biology, and allergies. Annotation c. by Book News, Inc., Portland, Or.
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IgE is the antibody isotype responsible for allergic reactions, a problem that affects 20% of the general population. An understanding of how, when and why IgE is produced is crucial to developing appropriate treatment for allergic disorders. This up-to-the-minute volume features:How T Cells direct IgE switchingIgE regulation in tissuesCytokine signal transduction and its role in isotype class switchingTranscription and switchingAntibody recognition of recombinant allergens and allergen-fragmentsIgE isoformsThis unique book will be invaluable to both basic scientists and clinicians in immunology, molecular biology and allergies.
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