Description
Leading clinicians and investigators review in a comprehensible and user-friendly style all the latest information about the molecular biology of cell cycle control and demonstrate its clinical relevance to understanding neoplastic diseases. Topics range from Cdk inhibitors and cell cycle regulators to the prognostic value of p27 and tumor suppressor genes as diagnostic tools. Actual case studies show how the new molecular understanding has produced such drugs as Flavopiridol and Sulindac. The book brings all the recent critical research findings to bear on clinical practice, and clearly shows their powerful impact on the diagnostics, prognostics, and therapeutics of cancer, AIDS, and cardiovascular disease.
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An accelerated and uncontrolled cycle of cell reproduction is no longer considered the primary mechanism of cancer, but is still taken into account as one of many factors in theoretical models for understanding, preventing, diagnosing, and curing cancer. Here researchers explain to physicians the clinical implications and uses of recent findings, especially from the increasingly popular molecular approach to understanding cell reproduction. Among the topics are tumor-suppressor genes as diagnostic tools, cell cycle regulatory genes as targets of retinoids, and modulators of cyclin-dependent kinases as a novel therapeutic approach for treating neoplastic diseases. Annotation c. Book News, Inc., Portland, OR (booknews.com)
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