Description
"Genetics and Genomics in Medicine is a new textbook written for undergraduate and graduate students, as well as medical researchers, which explains the science behind the uses of genetics and genomics in medicine today. It is not just about rare inherited and chromosomal disorders, but how genetics affects the whole spectrum of human health and disease. DNA technologies are explained, with emphasis on the modern techniques that have revolutionized the use of genetic information in medicine and are indicating the role of genetics in common complex diseases. The detailed, integrative coverage of genetic approaches to treatment and prevention includes pharmacogenomics and the prospects for personalized medicine. Cancers are essentially genetic diseases andare given a dedicated chapter that includes new insights from cancer genome sequencing. Clinical disorders are covered throughout and there are extensive end-of-chapter questions and problems"--
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This text outlines the principles of genetics and genomics as applied to medicine. It details the fundamentals of DNA, chromosomes, the cell cycle, human genome organization, and gene expression; the basics of three core molecular genetic approaches used to manipulate DNA (DNA amplification, nucleic acid hybridization, and DNA sequencing); the general principles of genetic variation, including DNA repair mechanisms and functional variation; how genes are transmitted in families and at allele frequencies in populations; how genes are regulated by protein and noncoding RNA regulators and the role of regulatory sequences in DNA and RNA; and clinical applications, including how chromosome abnormalities occur and their consequences, how mutations and large-scale DNA changes cause disease, how genes underlying single-gene disorders are identified, how genetic variants that confer susceptibility to complex diseases are identified, how genetic variants, epigenetic dysregulation, and environmental factors contribute to complex diseases, approaches for treating genetic disorders, cancer genetics and genomics, and diagnostic applications, genetic testing, and ethical considerations. Annotation ©2014 Ringgold, Inc., Portland, OR (protoview.com)
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